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CYTOCHROME-B(5) REDUCTASE
Descriptors Found:
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DeCS
Descriptor
English
:
Cytochrome-B(5) Reductase
Descriptor
Spanish
:
Citocromo-B(5) Reductasa
Descriptor
Portuguese
:
Citocromo-B(5) Redutase
Tree Number:
D08.811.682.608.191.237
D12.776.331.186
Definition
English
:
A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to
ALTERNATIVE SPLICING
of a single mRNA. The soluble form is present mainly in
ERYTHROCYTES
and is involved in the reduction of
METHEMOGLOBIN
. The membrane-bound form of the enzyme is found primarily in the
ENDOPLASMIC RETICULUM
and outer mitochondrial membrane, where it participates in the desaturation of
FATTY ACIDS
;
CHOLESTEROL
biosynthesis and drug
metabolism
. A deficiency in the enzyme can result in
METHEMOGLOBINEMIA.
Indexing Annotation
English
:
/defic: consider also
METHEMOGLOBINEMIA
History Note
English
:
2004; use CYTOCHROME B(5) REDUCTASE (NM) 1980-2003
Allowable Qualifiers
English
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
38212
Unique Identifier:
D042966
Occurrence in VHL
:
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